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Cisapride: Effective for treating acid reflux | Anzen Exports

October 6, 2021by Anzen_Exports0

Cisapride, an orally administered gastroprokinetic agent, increases motility in the upper gastrointestinal tract and is used to treat heartburn in patients suffering from gastroesophageal reflux disease (GERD). It also increases ‘gastric emptying’ in individuals suffering from diabetic gastroparesis. However, there is not much evidence regarding its efficacy in treating constipation.

The drug was discovered by Janssen Pharmaceuticals in the year 1980. Currently the drug has been either withdrawn from the market or had its indications limited in many countries (including India) owing to incidences of serious cardiac issues. [1]

Cisapride: Effective for treating acid reflux

Mechanism of action

Consumed as a tablet or a liquid orally, Cisapride acts through the stimulation of the serotonin 5-HT4 receptors that enhance acetylcholine release in the enteric nervous system. This release of this chemical messenger leads to increased tone and amplitude of gastric contractions, relaxation of the pyloric sphincter and the duodenal bulb that manifests into accelerated gastric emptying and intestinal transit. [2]

Cisapride: Effective for treating acid reflux

Side effects

Like any drug, Cisapride has been attributed to causing some side effects. The concerned medical practitioner must be informed if any of the below symptoms are severe:  [3]

  • Diarrhea
  • Stomach discomfort
  • Headache
  • Blocked nose
  • Constipation
  • Coughing
  • Changes in vision
  • Pain in the chest

Precautions [3, 4]

  • It is advisable to drink lots of fluids while on a course of this medicine to avoid dehydration caused by diarrhea.
  • The consumption of alcohol, operating machinery or driving a car while taking this drug should be avoided since it might cause acute drowsiness.
  • Inform the doctor if the patient is allergic to any drug or ever experienced intestinal disorders or bleeding ulcers.
  • The medical practitioner must be immediately informed if a patient becomes pregnant while on a course of Cisapride.
  • The drug can lead to very serious and irregular heartbeats, even resulting in death.
  • Do not drink grapejuice while consuming Cisapride.
  • The dosage should not exceed the amount that is already prescribed by the doctor.
  • Before consuming this drug, the patient must inform the doctor if he suffers from heart, kidney or liver disease.

Making quality medicines accessible to all

For over three decades now, Anzen Exports Pvt. Ltd. is a leading brand for manufacturing top quality Active Pharmaceutical Ingredients, herbal extracts, nutraceutical ingredients and cosmetic ingredients. Headquartered in Kolkata, this top Indian merchant export organization is vertically integrated in the domain of healthcare. The company has proven regulatory expertise as well as the required know-how for specialty formulations. Every member of the team works tirelessly towards the common goal of providing the best service possible for every need in the ever-changing landscape of the dynamic pharmaceutical industry.

For more information and to connect with the team, visit


Anzen Export’s blog posts are written with the information gathered from approved medical journals and websites online. Our research and technical team strive to provide relevant information through such articles. To be best informed, we advise consulting a doctor about an ingredient or medicine prior to taking it.


[1] Wikipedia [Online]:

[2] Drugbank Online [Online]:

[3] Medline Plus [Online]

[4] [Online]

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