Email :info@anzen.co.inCall Us : +91 33 24549650

Dosage & Side Effects of Levofloxacin | Anzen Exports

March 30, 2021by Anzen_Exports0

Levofloxacin an antibiotic for pneumonia
Levofloxacin is a third-generation, broad-spectrum antibiotic, which belongs to the fluoroquinolone drug class. It treats anthrax, plague, sinus, and urinary infection caused by bacteria. This drug is highly effective on bacterial infections and is used as a combination therapy.

The Food and Drug Administration has approved levofloxacin as a generic drug. It has four modes of administration; oral tablet, oral solution, ophthalmic solution, and intravenous form. It has no reaction to viral infections. (1)

Chemical Formulae – C18H20FN3O4.1/2 H20

Molecular Weight – 370.38g

Levofloxacin is the active pharmaceutical ingredient, which is combined with other chemical components to make the drug or the finished product. The finished product is marketed under different brand names.

Mechanism of Action

The major action of levofloxacin is to inhibit the DNA synthesis process of bacteria. It augments the breakage of DNA strands by restricting DNA-gyrase, which is an essential bacterial enzyme. DNA-gyrase helps in catalysing the negative supercoiling feature of closed circular double-stranded DNA, which is dependent on ATP.

Levofloxacin is reactive against gram-positive bacteria, which are penicillin-sensitive and resistant as well. It has a reduced effect on gram-negative bacilli.

It is one of the most effective antibiotics in its class and is used for a second line anti-tubercular therapy. It has high in-vitro activity. (2)

Also Read – World Antibiotic Awareness Week – 18th to 24th Nov 2020

Bioavailability

This medicine gets rapidly absorbed and evenly distributed in the body. Its bioavailability is 99% on applying either intravenously or orally. It is eliminated out through the renal route.

On which Bacteria Levofloxacin is Active?

  • Streptococcus pneumonia
  • Pseudomonas aeruginosa
  • Haemophilus influenzae
  • Moraxella catarrhalis
  • Legionella spp.
  • Mycoplasma spp.
  • Chlamydia pneumonia

Which Health Conditions are Treatable by Levofloxacin?

 

Dosage Details

DiseaseDoseDuration
Nosocomial Pneumonia750 mg7-14 days
Skin Infection750 mg7-14 days
Acute Bacterial Sinusitis500mg10-14 days
Urinary Tract Infection750 mg5 days
Acute Pyelonephritis500 mg5 days
Chronic Bronchitis500mg7 days
Chronic Bacterial Prostatitis500mg28 days
Anthrax250 mg60 days

 

It is advisable to take medicines as per the doctor’s advice. (3)

Side Effects

Serious side effects of levofloxacin are dizziness, nausea, increased heart rate, weakness, agitation, paranoia, seizures, skin rash, diarrhoea, and pain in the eye and stomach. Some others are shortness of breath, dark urine, paleness of eyes and skin, swelling and tearing of tendons, and mental/mood disorders.

Common side effects are lightheadedness, stomach pain/cramping, trouble in sleeping, and headache. (4)

Contraindication

  • Theophylline
  • Water pill or diuretic
  • Medicines related to arrhythmia
  • Insulin
  • Steroid
  • Blood thinner
  • Non-steroidal anti-inflammatory drug
  • Opioid medications
  • Medicine related to Marfan syndrome (5)

Supply of Levofloxacin

Anzen Exports is an exporter of active pharmaceutical ingredients across the world. We procure these medicinal components from some top notch manufacturers and supply those to companies making drugs.

Levofloxacin is one of our top selling products. We have more than 200 active pharmaceutical ingredients to prepare drugs related to various disciplines of medical treatment. Some of them are antibiotics, antidiabetic, anti-allergic, immunology, cardiovascular system, central nervous, genitourinary system, musculoskeletal disorders, dermatology, etc. Check our product page for a complete product list and send us an enquiry through the form available on our website or connect with our sales team. Read our upcoming blogs to get more insight on different diseases, precautionary measures, and medicines to use.

Sources:

  1. Healthline
    Website – https://www.healthline.com/health/levofloxacin-oral-tablet#highlights
  2. NCBI
    Website – https://www.ncbi.nlm.nih.gov/books/NBK545180/#:~:text=Levofloxacin%20is%20FDA%2Dapproved%20for,skin%20structure%20infections%2C%20prophylaxis%20and
  3. Medicine.org
    Website – https://www.medicines.org.uk/emc/product/6129/smpc#gref
  4. Michigan Medicine
    Website – https://www.uofmhealth.org/health-library/d04109a1
  5. Drugs.com
    Website – https://www.drugs.com/mtm/levofloxacin.html

Leave a Reply

Your email address will not be published. Required fields are marked *


Headquarters

Anzen Exports

20C Hazra Road, Kolkata 700026, West Bengal, India.info@anzen.co.in

+91 33 24549650

SOCIAL MEDIA

Follow Our Activity On





GET IN TOUCH

Subscribe to our Newsletter